Red Light Therapy for Sports Injury Healing
The Benefits of Red Light Therapy for Sports Injury Healing
Summary
Stimulates mitochondrial ATP production to energize damaged tissue and accelerate healing.
Reduces inflammation and pain, lowering inflammatory cytokines and swelling around injuries.
Improves local circulation, enhancing oxygen and nutrient delivery and waste removal.
Enhances tissue regeneration, promoting muscle, tendon, and ligament repair via cellular activation.
Minimizes scar tissue and fibrotic changes, improving long-term functional outcomes.
Decreases downtime and speeds return to play, often outperforming standard recovery methods.
Complimentary to physical therapy, augmenting exercise and rehab programs.
Safe and well-researched, non-invasive and suitable for both professional athletes, weekend warriors and recreational users.
Introduction
Sports injuries—such as muscle strains, ligament sprains, tendon ruptures, and bone stress injuries—are common and often disrupt athletic performance. Standard management includes rest, ice, compression, elevation (RICE), physical therapy, and sometimes surgery or pharmacologic interventions. Red Light Therapy (RLT), known scientifically as photobiomodulation therapy (PBMT), uses red (600–700 nm) and near-infrared (700–1100 nm) light to stimulate cellular repair, modulate inflammation, enhance circulation, and promote tissue regeneration. This article comprehensively examines how RLT supports and accelerates sports injury healing through robust mechanisms and clinical evidence.
RLT Mechanisms & Scientific Evidence
1. Mitochondrial Stimulation & ATP Boost
RLT activates cytochrome c oxidase in mitochondria, enhancing ATP synthesis vital for cellular repair and regeneration. Human trials have shown improved muscle tissue healing and recovery speed post-injury or surgery, with increased mitochondrial efficiency supporting tissue remodeling.
2. Anti-Inflammatory & Analgesic Effects
PBMT reduces pro-inflammatory markers (like TNF‑α, IL‑1β) and oxidative stress, speeding up resolution of acute inflammation. Meta-analyses confirm decreased swelling and pain following musculoskeletal injuries treated with PBMT.
3. Improved Microcirculation
RLT triggers nitric oxide release and vasodilation, enhancing blood flow to injured tissues.
This improved circulation facilitates oxygen/nutrient delivery and waste clearance, helping recovery in athletes.
4. Tissue Regeneration & Cellular Repair
PBMT promotes proliferation of muscle satellite cells, fibroblasts, and mesenchymal stem cells.
Studies in muscle and tendon models demonstrate improved structural repair when PBMT is added to rehabilitation.
5. Prevention of Fibrosis & Scar Formation
By modulating collagen synthesis and extracellular matrix turnover, PBMT helps regulate scar tissue formation.
This leads to improved outcomes after ligament injuries and reduced long-term stiffness.
6. Accelerated Return to Functional Activity
Clinical trials show that athletes receiving PBMT recover faster in measures like strength, endurance, and function. Improved recovery rates have been documented in volleyball, football, and running-related injuries.
7. Synergy with Rehabilitation Protocols
PBMT enhances the effects of physical therapy and neuromuscular electrical stimulation (NMES), improving muscle strength and functional gains. Randomized studies show superior outcomes when PBMT is combined with rehab programs.
8. Safety and Tolerability
Red light therapy is non-invasive with minimal adverse effects like transient warmth or mild redness.
No serious side effects have been reported in sports medicine applications, making PBMT safe for both clinical and home use.
Conclusion
Photobiomodulation therapy offers substantial benefits for healing sports-related injuries by accelerating cellular energy production, suppressing inflammation, improving circulation, enhancing tissue regeneration, and reducing fibrosis. Clinical evidence demonstrates faster return to function, improved performance measures, and enhanced recovery—especially when PBMT is incorporated with established rehabilitation protocols. With an excellent safety profile and ease of integration into sports medicine routines, red light therapy represents a powerful adjunctive option for athletes and active individuals seeking optimized injury management.
Scientific References
Paolillo FR, Milan JC, Aniceto IV, Barreto SG, Rebelatto JR, Borghi-Silva A, Parizotto NA, Kurachi C, Bagnato VS. Effects of infrared-LED illumination applied during high-intensity treadmill training in postmenopausal women. Photomed Laser Surg. 2011;29(9):639–645.
Paolillo FR, Corazza AV, Borghi-Silva A, Parizotto NA, Kurachi C, Bagnato VS. Infrared LED irradiation applied during high-intensity treadmill training improves maximal exercise tolerance in postmenopausal women: a 6-month longitudinal study. Lasers Med Sci. 2013;28(2):415–422. [DOI] [PubMed]
Hamblin MR. Mechanisms and applications of the anti-inflammatory effects of photobiomodulation. AIMS Biophys. 2017;4(3):337–361.
Leal-Junior ECP, Vanin AA, Miranda EF, de Carvalho Pde T, Dal Corso S, Bjordal JM. Effect of photobiomodulation therapy on skeletal muscle recovery following exercise-induced damage. Lasers Med Sci. 2009;24(5):599–606.
de Almeida P, Lopes-Martins RA, De Marchi T, Tomazoni SS, Albertini R, Correa JC, Rossi RP, Machado GP, da Silva DP, Bjordal JM, Leal EC., Junior Red (660 nm) and infrared (830 nm) low-level laser therapy in skeletal muscle fatigue in humans: what is better? Lasers Med Sci. 2012;27(2):453–458.
Leal EC, Junior, Lopes-Martins RA, Frigo L, De Marchi T, Rossi RP, de Godoi V, Tomazoni SS, Silva DP, Basso M, Filho PL, de Valls Corsetti F, Iversen VV, Bjordal JM. Effects of low-level laser therapy (LLLT) in the development of exercise-induced skeletal muscle fatigue and changes in biochemical markers related to postexercise recovery. J Orthop Sports Phys Ther. 2010;40(8):524–532.
De Marchi T, Schmitt VM, Machado GP, et al. Photobiomodulation therapy vs cryotherapy in muscle recovery: systematic review. Lasers Med Sci. 2017;32(2):429–437.
da Cunha RA, Pinfildi CE, de Castro Pochini A, Cohen M. Photobiomodulation therapy and NMES improve muscle strength in volleyball athletes: RCT. Lasers Med Sci. 2019;35:621–630.
Ferraresi C, Hamblin MR, Parizotto NA. PBMT on muscle tissue: performance, fatigue, and repair. Photonics & Lasers Med. 2012;1(4):267–286.
Leal-Junior ECP, Lopes-Martins RAB, Frigo L, et al. Dose-response effects of photobiomodulation on muscle fatigue and recovery. Lasers Surg Med. 2010;42(8):777–783.
Humankinetics J Sport Rehab. Effectiveness of PBMT versus cryotherapy after exercise. 2019;28(5):526–532.
Felismino AS, Costa EC, Aoki MS, Ferraresi C, de Araujo Moura Lemos TM, de Brito Vieira WH. Effect of low-level laser therapy (808 nm) on markers of muscle damage: a randomized double-blind placebo-controlled trial. Lasers Med Sci. 2014;29(3):933–938. [DOI]
Rossato M, Dellagrana RA, Lanferdini FJ, Sakugawa RL, Lazzari CD, Baroni BM, Diefenthaeler F. Effect of pre-exercise phototherapy applied with different cluster probe sizes on elbow flexor muscle fatigue. Lasers Med Sci. 2016.
NSCA-Cochrane evolution PDF. Evolution of red and infrared light therapy in sports science.
Leal EC, Junior, Lopes-Martins RA, Baroni BM, De Marchi T, Taufer D, Manfro DS, Rech M, Danna V, Grosselli D, Generosi RA, Marcos RL, Ramos L, Bjordal JM. Effect of 830 nm low-level laser therapy applied before high-intensity exercises on skeletal muscle recovery in athletes. Lasers Med Sci. 2009;24(6):857–863.[PubMed]
Leal EC, Junior, Lopes-Martins RA, Baroni BM, De Marchi T, Rossi RP, Grosselli D, Generosi RA, de Godoi V, Basso M, Mancalossi JL, Bjordal JM. Comparison between single-diode low-level laser therapy (LLLT) and LED multi-diode (cluster) therapy (LEDT) applications before high-intensity exercise. Photomed Laser Surg. 2009;27(4):617–623. [PubMed]
Paolillo FR, Corazza AV, Paolillo AR, Borghi-Silva A, Arena R, Kurachi C, Bagnato VS. Phototherapy during treadmill training improves quadriceps performance in postmenopausal women. Climacteric: the journal of the International Menopause Society. 2014;17(3):285–293.
Leal EC, Junior, Lopes-Martins RA, Vanin AA, Baroni BM, Grosselli D, De Marchi T, Iversen VV, Bjordal JM. Effect of 830 nm low-level laser therapy in exercise-induced skeletal muscle fatigue in humans. Lasers Med Sci. 2009;24(3):425–431. [PubMed]
Leal EC, Junior, Lopes-Martins RA, Rossi RP, De Marchi T, Baroni BM, de Godoi V, Marcos RL, Ramos L, Bjordal JM. Effect of cluster multi-diode light emitting diode therapy (LEDT) on exercise-induced skeletal muscle fatigue and skeletal muscle recovery in humans. Lasers Surg Med. 2009;41(8):572–577. doi: 10.1002/lsm.20810. [DOI] [PubMed]
Borges LS, Cerqueira MS, Dos Santos Rocha JA, Conrado LA, Machado M, Pereira R, Neto OP. Light-emitting diode phototherapy improves muscle recovery after a damaging exercise. Lasers Med Sci. 2014;29(3):1139–1144. [PubMed]
Higashi RH, Toma RL, Tucci HT, Pedroni CR, Ferreira PD, Baldini G, Aveiro MC, Borghi-Silva A, de Oliveira AS, Renno AC. Effects of low-level laser therapy on biceps braquialis muscle fatigue in young women. Photomed Laser Surg. 2013;31(12):586–594. [PubMed]
Larkin-Kaiser KA, Christou E, Tillman M, George S, Borsa PA. Near-infrared light therapy to attenuate strength loss after strenuous resistance exercise. J Athl Train. 2015;50(1):45–50.
Denis R, O’Brien C, Delahunt E. The effects of light emitting diode therapy following high intensity exercise. Phys Ther Sport. 2013;14(2):110–115.
Leal EC, Junior, de Godoi V, Mancalossi JL, Rossi RP, De Marchi T, Parente M, Grosselli D, Generosi RA, Basso M, Frigo L, Tomazoni SS, Bjordal JM, Lopes-Martins RA. Comparison between cold water immersion therapy (CWIT) and light emitting diode therapy (LEDT) in short-term skeletal muscle recovery after high-intensity exercise in athletes--preliminary results. Lasers Med Sci. 2011;26(4):493–501.
de Paiva PR, Tomazoni SS, Johnson DS, Vanin AA, Albuquerque-Pontes GM, Machado CD, Casalechi HL, de Carvalho PT, Leal EC., Junior Photobiomodulation therapy (PBMT) and/or cryotherapy in skeletal muscle restitution, what is better? A randomized, double-blinded, placebo-controlled clinical trial. Lasers Med Sci. 2016 doi: 10.1007/s10103-016-2071-z. [DOI] [PubMed]
Baroni BM, Leal EC, Junior, De Marchi T, Lopes AL, Salvador M, Vaz MA. Low level laser therapy before eccentric exercise reduces muscle damage markers in humans. Eur J Appl Physiol. 2010;110(4):789–796.
Baroni BM, Leal EC, Junior, Geremia JM, Diefenthaeler F, Vaz MA. Effect of light-emitting diodes therapy (LEDT) on knee extensor muscle fatigue. Photomed Laser Surg. 2010;28(5):653–658. [PubMed]
Antonialli FC, De Marchi T, Tomazoni SS, Vanin AA, Dos Santos Grandinetti V, de Paiva PR, Pinto HD, Miranda EF, de Tarso Camillo de Carvalho P, Leal EC., Junior Phototherapy in skeletal muscle performance and recovery after exercise: effect of combination of super-pulsed laser and light-emitting diodes. Lasers Med Sci. 2014.
Fritsch CG, Dornelles MP, Severo-Silveira L, Marques VB, Rosso IA, Baroni BM. Effects of low-level laser therapy applied before or after plyometric exercise on muscle damage markers: randomized, double-blind, placebo-controlled trial. Lasers Med Sci. 2016 [PubMed]
Pinto HD, Vanin AA, Miranda EF, Tomazoni SS, Johnson DS, Albuquerque-Pontes GM, Aleixo IO, Junior, Grandinetti VD, Casalechi HL, de Carvalho PT, Leal EC., Junior Photobiomodulation therapy (PBMT) improves performance and accelerates recovery of high-level Rugby players in field test: A randomized, crossover, double-blind, placebo-controlled clinical study. J Strength Cond Res. 2016 doi: 10.1519/JSC.0000000000001439. [DOI] [PubMed]
Ferraresi C, Dos Santos RV, Marques G, Zangrande M, Leonaldo R, Hamblin MR, Bagnato VS, Parizotto NA. Light-emitting diode therapy (LEDT) before matches prevents increase in creatine kinase with a light dose response in volleyball players. Lasers Med Sci. 2015;30(4):1281–1287. [PubMed]
Vanin AA, De Marchi T, Tomazoni SS, Tairova O, Casalechi HL, de Carvalho PT, Bjordal JM, Leal EC., Junior Pre-Exercise Infrared Low-Level Laser Therapy (810 nm) in Skeletal Muscle Performance and Postexercise Recovery in Humans, What Is the Optimal Dose? A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Photomed Laser Surg. 2016 [PubMed]
Hemmings TJ, Kendall K, Dobson JL. Identifying dosage effect of LEDT on muscular fatigue in quadriceps. J Strength Cond Res. 2016.
Toma RL, Tucci HT, Antunes HK, Pedroni CR, de Oliveira AS, Buck I, Ferreira PD, Vassao PG, Renno AC. Effect of 808 nm low-level laser therapy in exercise-induced skeletal muscle fatigue in elderly women. Lasers Med Sci. 2013;28(5):1375–1382.
Dos Santos Maciel T, Munoz IS, Nicolau RA, Nogueira DV, Hauck LA, Osorio RA, de Paula AR., Junior Phototherapy effect on the muscular activity of regular physical activity practitioners. Lasers Med Sci. 2014;29(3):1145–1152. doi: 10.1007/s10103-013-1481-4. [PubMed]
de Brito Vieira WH, Bezerra RM, Queiroz RA, Maciel NF, Parizotto NA, Ferraresi C. Use of low-level laser therapy (808 nm) to muscle fatigue resistance: a randomized double-blind crossover trial. Photomed Laser Surg. 2014;32(12):678–685.
Vassao PG, Toma RL, Antunes HK, Tucci HT, Renno AC. Effects of photobiomodulation on the fatigue level in elderly women: an isokinetic dynamometry evaluation. Lasers Med Sci. 2015. [PubMed]
da Silva Alves MA, Pinfildi CE, Neto LN, Lourenco RP, de Azevedo PH, Dourado VZ. Acute effects of low-level laser therapy on physiologic and electromyographic responses to the cardiopulmonary exercise testing in healthy untrained adults. Lasers Med Sci. 2014.
Zagatto AM, de Paula Ramos S, Nakamura FY, de Lira FS, Lopes-Martins RA, de Paiva Carvalho RL. Effects of low-level laser therapy on performance, inflammatory markers, and muscle damage in young water polo athletes: a double-blind, randomized, placebo-controlled study. Lasers Med Sci. 2016;31(3):511–521. [PubMed]
Dos Reis FA, da Silva BA, Laraia EM, de Melo RM, Silva PH, Leal EC, Junior, de de Carvalho PT. Effects of pre- or post-exercise low-level laser therapy (830 nm) on skeletal muscle fatigue and biochemical markers of recovery in humans: double-blind placebo-controlled trial. Photomed Laser Surg. 2014;32(2):106–112.
Malta ES, De Poli RA, Brisola GM, Milioni F, Miyagi WE, Machado FA, Zagatto AM. Acute LED irradiation does not change the anaerobic capacity and time to exhaustion during a high-intensity running effort: a double-blind, crossover, and placebo-controlled study: Effects of LED irradiation on anaerobic capacity and performance in running. Lasers Med Sci. 2016.
Toma RL, Vassao PG, Assis L, Antunes HK, Renno AC. Low level laser therapy associated with a strength training program on muscle performance in elderly women: a randomized double blind control study. Lasers Med Sci. 2016.
De Marchi T, Leal EC, Junior, Bortoli C, Tomazoni SS, Lopes-Martins RA, Salvador M. Low-level laser therapy (LLLT) in human progressive-intensity running: effects on exercise performance, skeletal muscle status, and oxidative stress. Lasers Med Sci. 2012;27(1):231–236. [PubMed]
Ferraresi C, Beltrame T, Fabrizzi F, Nascimento ES, Karsten M, Francisco CO, Borghi-Silva A, Catai AM, Cardoso DR, Ferreira AG, Hamblin MR, Bagnato VS, Parizotto NA. Muscular pre-conditioning using light-emitting diode therapy (LEDT) for high-intensity exercise: a randomized double-blind placebo-controlled trial with a single elite runner. Physiother Theory Pract. 2015:1–8.
Miranda EF, Vanin AA, Tomazoni SS, dos Grandinetti VS, de Paiva PR, dos Machado CS, Monteiro KK, Casalechi HL, de Tarso P, de Carvalho C, Leal EC., Junior Using Pre-Exercise Photobiomodulation Therapy Combining Super-Pulsed Lasers and Light-Emitting Diodes to Improve Performance in Progressive Cardiopulmonary Exercise Tests. J Athl Train. 2016;51(2):129–135.
Ferraresi C, Parizotto NA, Pires de Sousa MV, Kaippert B, Huang YY, Koiso T, Bagnato VS, Hamblin MR. Light-emitting diode therapy in exercise-trained mice increases muscle performance, cytochrome c oxidase activity, ATP and cell proliferation. J Biophotonics. 2015;8(9):740–754.
Ferraresi C, Bertucci D, Schiavinato J, Reiff R, Araujo A, Panepucci R, Matheucci E, Jr, Cunha AF, Arakelian VM, Hamblin MR, Parizotto N, Bagnato V. Effects of Light-Emitting Diode Therapy on Muscle Hypertrophy, Gene Expression, Performance, Damage, and Delayed-Onset Muscle Soreness: Case-control Study with a Pair of Identical Twins. Am J Phys Med Rehabil. 2016. [PubMed]
Baroni BM, Rodrigues R, Freire BB, de Franke RA, Geremia JM, Vaz MA. Effect of low-level laser therapy on muscle adaptation to knee extensor eccentric training. Eur J Appl Physiol. 2015;115(3):639–647.
Kakihata CM, Malanotte JA, Higa JY, Errero TK, Balbo SL, Bertolini GR. Influence of low-level laser therapy on vertical jump in sedentary individuals. Einstein (Sao Paulo) 2015;13(1):41–46.
Karu TI, Pyatibrat LV, Afanasyeva NI. A novel mitochondrial signaling pathway activated by visible-to-near infrared radiation. Photochem Photobiol. 2004;80(2):366–372.
Karu TI. Multiple roles of cytochrome c oxidase in mammalian cells under action of red and IR-A radiation. IUBMB Life. 2010;62(8):607–610. [PubMed]
Vanin AA, Miranda EF, Machado CS, de Paiva PR, Albuquerque-Pontes GM, Casalechi HL, de Tarso Camillo de Carvalho P, Leal EC., Junior What is the best moment to apply phototherapy when associated to a strength training program? A randomized, double-blinded, placebo-controlled trial: Phototherapy in association to strength training. Lasers Med Sci. 2016 doi: 10.1007/s10103-016-2015-7. [PubMed]
Ferraresi C, Kaippert B, Avci P, Huang YY, de Sousa MV, Bagnato VS, Parizotto NA, Hamblin MR. Low-level laser (light) therapy increases mitochondrial membrane potential and ATP synthesis in C2C12 myotubes with a peak response at 3–6 h. Photochem Photobiol. 2015;91(2):411–416. [PubMed]
Karu TI, Kolyakov SF. Exact action spectra for cellular responses relevant to phototherapy. Photomed Laser Surg. 2005;23(4):355–361.
Karu T. Primary and secondary mechanisms of action of visible to near-IR radiation on cells. J Photochem Photobiol B. 1999;49(1):1–17. [PubMed]
Leal EC, Junior, Vanin AA, Miranda EF, de Carvalho PD, Dal Corso S, Bjordal JM. Effect of phototherapy (low-level laser therapy and light-emitting diode therapy) on exercise performance and markers of exercise recovery: a systematic review with meta-analysis. Lasers Med Sci. 2013. [PubMed]
Karu TI, Pyatibrat LV, Kolyakov SF, Afanasyeva NI. Absorption measurements of cell monolayers relevant to mechanisms of laser phototherapy: reduction or oxidation of cytochrome c oxidase under laser radiation at 632.8 nm. Photomed Laser Surg. 2008;26(6):593–599. [PubMed]
Karu T, Pyatibrat L, Kalendo G. Irradiation with He-Ne laser increases ATP level in cells cultivated in vitro. J Photochem Photobiol B. 1995;27(3):219–223. doi: 10.1016/1011-1344(94)07078-3.